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Topic: skills

17,247 skills in this topic.

gget CLI/Python toolkit for rapid bioinformatics queries. Preferred for quick BLAST searches. Access to 20+ databases: gene info (Ensembl/UniProt), AlphaFold, ARCHS4, Enrichr, OpenTargets, COSMIC, genome downloads. For advanced BLAST/batch processing, use biopython. For multi-database integration, use bioservices.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
brenda-database Access BRENDA enzyme database via SOAP API. Retrieve kinetic parameters (Km, kcat), reaction equations, organism data, and substrate-specific enzyme information for biochemical research and metabolic pathway analysis.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-atac-seq-differential-accessibility Find differentially accessible chromatin regions between conditions using DiffBind or DESeq2. Use when comparing chromatin accessibility between treatment groups, cell types, or developmental stages in ATAC-seq experiments.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-single-cell-cell-communication Infer cell-cell communication networks from scRNA-seq data using CellChat, NicheNet, and LIANA for ligand-receptor interaction analysis. Use when inferring ligand-receptor interactions between cell types.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-structural-biology-modern-structure-prediction Predict protein structures using modern ML models including AlphaFold3, ESMFold, Chai-1, and Boltz-1. Use when predicting structures for novel proteins, protein complexes, or when comparing predictions across multiple methods.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
tumor-clonal-evolution-agent
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-read-qc-adapter-trimming Remove sequencing adapters from FASTQ files using Cutadapt and Trimmomatic. Supports single-end and paired-end reads, Illumina TruSeq, Nextera, and custom adapter sequences. Use when FastQC shows adapter contamination or before alignment of short reads.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
claw-ancestry-pca Ancestry decomposition PCA against the Simons Genome Diversity Project
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
pydeseq2 Differential gene expression analysis (Python DESeq2). Identify DE genes from bulk RNA-seq counts, Wald tests, FDR correction, volcano/MA plots, for RNA-seq analysis.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
protein-qc Quality control metrics and filtering thresholds for protein design. Use this skill when: (1) Evaluating design quality for binding, expression, or structure, (2) Setting filtering thresholds for pLDDT, ipTM, PAE, (3) Checking sequence liabilities (cysteines, deamidation, polybasic clusters), (4) Creating multi-stage filtering pipelines, (5) Computing PyRosetta interface metrics (dG, SC, dSASA), (6) Checking biophysical properties (instability, GRAVY, pI), (7) Ranking designs with composite scoring. This skill provides research-backed thresholds from binder design competitions and published benchmarks.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
spatial-transcriptomics-agent
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-workflows-smrna-pipeline
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-molecular-descriptors Calculates molecular descriptors and fingerprints using RDKit. Computes Morgan fingerprints (ECFP), MACCS keys, Lipinski properties, QED drug-likeness, TPSA, and 3D conformer descriptors. Use when featurizing molecules for machine learning or filtering by drug-likeness criteria.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-epitranscriptomics-m6a-peak-calling
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
polars Fast in-memory DataFrame library for datasets that fit in RAM. Use when pandas is too slow but data still fits in memory. Lazy evaluation, parallel execution, Apache Arrow backend. Best for 1-100GB datasets, ETL pipelines, faster pandas replacement. For larger-than-RAM data use dask or vaex.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-clinical-databases-gnomad-frequencies Query gnomAD for population allele frequencies to assess variant rarity. Use when filtering variants by population frequency for rare disease analysis or determining if a variant is common in the general population.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
torch-geometric Graph Neural Networks (PyG). Node/graph classification, link prediction, GCN, GAT, GraphSAGE, heterogeneous graphs, molecular property prediction, for geometric deep learning.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
labarchive-integration Electronic lab notebook API integration. Access notebooks, manage entries/attachments, backup notebooks, integrate with Protocols.io/Jupyter/REDCap, for programmatic ELN workflows.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
parameter-optimization Explore and optimize simulation parameters via design of experiments (DOE), sensitivity analysis, and optimizer selection. Use for calibration, uncertainty studies, parameter sweeps, LHS sampling, Sobol analysis, surrogate modeling, or Bayesian optimization setup.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-isoform-switching Analyzes isoform switching events and functional consequences using IsoformSwitchAnalyzeR. Predicts protein domain changes, NMD sensitivity, ORF alterations, and coding potential shifts between conditions. Use when investigating how splicing changes affect protein function.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-spatial-transcriptomics-spatial-domains Identify spatial domains and tissue regions in spatial transcriptomics data using Squidpy and Scanpy. Cluster spots considering both expression and spatial context to define anatomical regions. Use when identifying tissue domains or spatial regions.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
paper-2-web This skill should be used when converting academic papers into promotional and presentation formats including interactive websites (Paper2Web), presentation videos (Paper2Video), and conference posters (Paper2Poster). Use this skill for tasks involving paper dissemination, conference preparation, creating explorable academic homepages, generating video abstracts, or producing print-ready posters from LaTeX or PDF sources.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-splicing-qc Assesses RNA-seq data quality for splicing analysis including junction saturation curves, splice site strength scoring, and junction coverage metrics using RSeQC. Use when evaluating data suitability for splicing analysis or troubleshooting low event detection.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
trialgpt-matching
FreedomIntelligence/OpenClaw-Medical-Skills 2,009