Topic: skills
17,247 skills in this topic.
-
executing-plans
Use when you have a written implementation plan to execute in a separate session with review checkpoints
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
tooluniverse-antibody-engineering
Comprehensive antibody engineering and optimization for therapeutic development. Covers humanization, affinity maturation, developability assessment, and immunogenicity prediction. Use when asked to optimize antibodies, humanize sequences, or engineer therapeutic antibodies from lead to clinical candidate.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
depmap
Query the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores (CRISPR Chronos), drug sensitivity data, and gene effect profiles. Use for identifying cancer-specific vulnerabilities, synthetic lethal interactions, and validating oncology drug targets.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
chemical-property-lookup
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
bindingdb-database
Query BindingDB for measured drug-target binding affinities (Ki, Kd, IC50, EC50). Search by target (UniProt ID), compound (SMILES/name), or pathogen. Essential for drug discovery, lead optimization, polypharmacology analysis, and structure-activity relationship (SAR) studies.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
bioinformatics-singlecell
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
crispr-offtarget-predictor
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
bio-fastq-quality
Work with FASTQ quality scores using Biopython. Use when analyzing read quality, filtering by quality, trimming low-quality bases, or generating quality reports.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
lamindb
This skill should be used when working with LaminDB, an open-source data framework for biology that makes data queryable, traceable, reproducible, and FAIR. Use when managing biological datasets (scRNA-seq, spatial, flow cytometry, etc.), tracking computational workflows, curating and validating data with biological ontologies, building data lakehouses, or ensuring data lineage and reproducibility in biological research. Covers data management, annotation, ontologies (genes, cell types, diseases, tissues), schema validation, integrations with workflow managers (Nextflow, Snakemake) and MLOps platforms (W&B, MLflow), and deployment strategies.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
bio-variant-calling-clinical-interpretation
Clinical variant interpretation using ClinVar, ACMG guidelines, and pathogenicity predictors. Prioritize variants for diagnostic and research applications. Use when interpreting clinical significance of variants.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
chemcrow-drug-discovery
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
bio-causal-genomics-mediation-analysis
Decompose genetic effects into direct and indirect paths through mediating variables using the mediation R package. Tests whether gene expression, methylation, or other molecular phenotypes mediate the effect of genetic variants on disease. Use when testing whether a molecular phenotype mediates the genotype-to-phenotype relationship.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
gwas-prs
Calculate polygenic risk scores from DTC genetic data using the PGS Catalog
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
rdkit
Cheminformatics toolkit for fine-grained molecular control. SMILES/SDF parsing, descriptors (MW, LogP, TPSA), fingerprints, substructure search, 2D/3D generation, similarity, reactions. For standard workflows with simpler interface, use datamol (wrapper around RDKit). Use rdkit for advanced control, custom sanitization, specialized algorithms.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
bio-chipseq-peak-calling
ChIP-seq peak calling using MACS3 (or MACS2). Call narrow peaks for transcription factors or broad peaks for histone modifications. Supports input control, fragment size modeling, and various output formats including narrowPeak and broadPeak BED files. Use when calling peaks from ChIP-seq alignments.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
bio-read-qc-contamination-screening
Detect sample contamination and cross-species reads using FastQ Screen. Screen reads against multiple reference genomes to identify bacterial, viral, adapter, or sample swap contamination. Use when suspecting cross-contamination or working with samples prone to microbial contamination.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
bio-workflows-riboseq-pipeline
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
bio-differential-expression-timeseries-de
Analyze time-series RNA-seq data using limma voom with splines, maSigPro, and ImpulseDE2. Identify genes with dynamic expression patterns. Use when analyzing time-series or longitudinal expression data.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
hypogenic
Automated hypothesis generation and testing using large language models. Use this skill when generating scientific hypotheses from datasets, combining literature insights with empirical data, testing hypotheses against observational data, or conducting systematic hypothesis exploration for research discovery in domains like deception detection, AI content detection, mental health analysis, or other empirical research tasks.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
bio-pathway-wikipathways
WikiPathways enrichment using clusterProfiler and rWikiPathways. Use when analyzing gene lists against community-curated open-source pathways. Performs over-representation analysis and GSEA for 30+ species.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
bio-rna-quantification-count-matrix-qc
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
compbioagent-explorer
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
literature-review
Conduct comprehensive, systematic literature reviews using multiple academic databases (PubMed, arXiv, bioRxiv, Semantic Scholar, etc.). This skill should be used when conducting systematic literature reviews, meta-analyses, research synthesis, or comprehensive literature searches across biomedical, scientific, and technical domains. Creates professionally formatted markdown documents and PDFs with verified citations in multiple citation styles (APA, Nature, Vancouver, etc.).
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
-
bulk-wgcna-analysis-with-omicverse
Assist Claude in running PyWGCNA through omicverse—preprocessing expression matrices, constructing co-expression modules, visualising eigengenes, and extracting hub genes.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009