Topic: skills
17,247 skills in this topic.
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bio-methylation-methylkit
DNA methylation analysis with methylKit in R. Import Bismark coverage files, filter by coverage, normalize samples, and perform statistical comparisons. Use when analyzing single-base methylation patterns, comparing samples, or preparing data for DMR detection.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-metagenomics-abundance
Species abundance estimation using Bracken with Kraken2 output. Redistributes reads from higher taxonomic levels to species for more accurate estimates. Use when accurate species-level abundances are needed from Kraken2 classification output.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-spatial-transcriptomics-image-analysis
Process and analyze tissue images from spatial transcriptomics data using Squidpy. Extract image features, segment cells/nuclei, and compute morphological features from H&E or IF images. Use when processing tissue images for spatial transcriptomics.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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epigenomics-methylgpt-agent
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-chipseq-qc
ChIP-seq quality control metrics including FRiP (Fraction of Reads in Peaks), cross-correlation analysis (NSC/RSC), library complexity, and IDR (Irreproducibility Discovery Rate) for replicate concordance. Use to assess experiment quality before downstream analysis. Use when assessing ChIP-seq data quality metrics.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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spatial-agent
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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molecule-evolution-agent
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-flow-cytometry-compensation-transformation
Spillover compensation and data transformation for flow cytometry. Covers compensation matrix calculation, application, and biexponential/arcsinh transforms. Use when correcting spectral overlap between fluorophores or transforming data for analysis.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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medrxiv-search
Search medRxiv medical preprints with natural language queries. Powered by Valyu semantic search.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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tiledbvcf
Efficient storage and retrieval of genomic variant data using TileDB. Scalable VCF/BCF ingestion, incremental sample addition, compressed storage, parallel queries, and export capabilities for population genomics.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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convergence-study
Spatial and temporal convergence analysis with Richardson extrapolation and Grid Convergence Index (GCI) for solution verification
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-hi-c-analysis-hic-data-io
Load, convert, and manipulate Hi-C contact matrices using cooler format. Read .cool/.mcool files, convert from .hic format, access matrix data, and export to different formats. Use when loading or converting Hi-C contact matrices.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-workflows-metabolomics-pipeline
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-comparative-genomics-ancestral-reconstruction
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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alphafold-database
Access AlphaFold's 200M+ AI-predicted protein structures. Retrieve structures by UniProt ID, download PDB/mmCIF files, analyze confidence metrics (pLDDT, PAE), for drug discovery and structural biology.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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pdf-processing-pro
Production-ready PDF processing with forms, tables, OCR, validation, and batch operations. Use when working with complex PDF workflows in production environments, processing large volumes of PDFs, or requiring robust error handling and validation.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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scikit-survival
Comprehensive toolkit for survival analysis and time-to-event modeling in Python using scikit-survival. Use this skill when working with censored survival data, performing time-to-event analysis, fitting Cox models, Random Survival Forests, Gradient Boosting models, or Survival SVMs, evaluating survival predictions with concordance index or Brier score, handling competing risks, or implementing any survival analysis workflow with the scikit-survival library.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-long-read-sequencing-nanopore-methylation
Calls DNA methylation from Oxford Nanopore sequencing data using signal-level analysis. Use when detecting 5mC or 6mA modifications directly from nanopore reads without bisulfite conversion.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-workflows-hic-pipeline
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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tooluniverse-variant-analysis
Production-ready VCF processing, variant annotation, mutation analysis, and structural variant (SV/CNV) interpretation for bioinformatics questions. Parses VCF files (streaming, large files), classifies mutation types (missense, nonsense, synonymous, frameshift, splice, intronic, intergenic) and structural variants (deletions, duplications, inversions, translocations), applies VAF/depth/quality/consequence filters, annotates with ClinVar/dbSNP/gnomAD/CADD via ToolUniverse, interprets SV/CNV clinical significance using ClinGen dosage sensitivity scores, computes variant statistics, and generates reports. Solves questions like "What fraction of variants with VAF < 0.3 are missense?", "How many non-reference variants remain after filtering intronic/intergenic?", "What is the pathogenicity of this deletion affecting BRCA1?", or "Which dosage-sensitive genes overlap this CNV?". Use when processing VCF files, annotating variants, filtering by VAF/depth/consequence, classifying mutations, interpreting structural variants, assessing CNV pathogenicity, comparing cohorts, or answering variant analysis questions.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-compressed-files
Read and write compressed sequence files (gzip, bzip2, BGZF) using Biopython. Use when working with .gz or .bz2 sequence files. Use BGZF for indexable compressed files.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-clip-seq-clip-motif-analysis
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-metabolomics-lipidomics
Specialized lipidomics analysis for lipid identification, quantification, and pathway interpretation. Covers LC-MS lipidomics with LipidSearch, MS-DIAL, and LipidMaps annotation. Use when analyzing lipid classes, chain composition, or lipid-specific pathways.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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biorxiv-database
Efficient database search tool for bioRxiv preprint server. Use this skill when searching for life sciences preprints by keywords, authors, date ranges, or categories, retrieving paper metadata, downloading PDFs, or conducting literature reviews.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009