Topic: skills
17,247 skills in this topic.
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alphafold
Validate protein designs using AlphaFold2 structure prediction. Use this skill when: (1) Validating designed sequences fold correctly, (2) Predicting binder-target complex structures, (3) Calculating confidence metrics (pLDDT, pTM, ipTM), (4) Self-consistency validation of designs, (5) Multi-chain complex prediction with AlphaFold-Multimer.
For faster single-chain prediction, use esm. For QC thresholds, use protein-qc.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-single-cell-multimodal-integration
Analyze multi-modal single-cell data (CITE-seq, Multiome, spatial). Use when working with data that measures multiple modalities per cell like RNA + protein or RNA + ATAC. Use when analyzing CITE-seq, Multiome, or other multi-modal single-cell data.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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differentiation-schemes
Select and apply numerical differentiation schemes for PDE/ODE discretization. Use when choosing finite difference/volume/spectral schemes, building stencils, handling boundaries, estimating truncation error, or analyzing dispersion and dissipation.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-clinical-databases-polygenic-risk
Calculate polygenic risk scores using PRSice-2, LDpred2, or PRS-CS from GWAS summary statistics. Use when predicting disease risk from genome-wide genetic variants.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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opentargets-database
Query Open Targets Platform for target-disease associations, drug target discovery, tractability/safety data, genetics/omics evidence, known drugs, for therapeutic target identification.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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spatial-domains
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-clip-seq-clip-preprocessing
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-copy-number-cnv-annotation
Annotate CNVs with genes, pathways, and clinical significance. Use when interpreting CNV calls or identifying affected genes from copy number analysis.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-alignment-files-bam-statistics
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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dask
Distributed computing for larger-than-RAM pandas/NumPy workflows. Use when you need to scale existing pandas/NumPy code beyond memory or across clusters. Best for parallel file processing, distributed ML, integration with existing pandas code. For out-of-core analytics on single machine use vaex; for in-memory speed use polars.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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medical-entity-extractor
Extract medical entities (symptoms, medications, lab values, diagnoses) from patient messages.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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linear-solvers
Select and configure linear solvers for systems Ax=b in dense and sparse problems. Use when choosing direct vs iterative methods, diagnosing convergence issues, estimating conditioning, selecting preconditioners, or debugging stagnation in GMRES/CG/BiCGSTAB.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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tooluniverse-sequence-retrieval
Retrieves biological sequences (DNA, RNA, protein) from NCBI and ENA with gene disambiguation, accession type handling, and comprehensive sequence profiles. Creates detailed reports with sequence metadata, cross-database references, and download options. Use when users need nucleotide sequences, protein sequences, genome data, or mention GenBank, RefSeq, EMBL accessions.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-research-tools-biomarker-signature-studio
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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scientific-problem-selection
This skill should be used when scientists need help with research problem selection, project ideation, troubleshooting stuck projects, or strategic scientific decisions. Use this skill when users ask to pitch a new research idea, work through a project problem, evaluate project risks, plan research strategy, navigate decision trees, or get help choosing what scientific problem to work on. Typical requests include "I have an idea for a project", "I'm stuck on my research", "help me evaluate this project", "what should I work on", or "I need strategic advice about my research".
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bulk-rna-seq-deseq2-analysis-with-omicverse
Walk Claude through PyDESeq2-based differential expression, including ID mapping, DE testing, fold-change thresholding, and enrichment visualisation.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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scientific-brainstorming
Research ideation partner. Generate hypotheses, explore interdisciplinary connections, challenge assumptions, develop methodologies, identify research gaps, for creative scientific problem-solving.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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microbiome-cancer-agent
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-rnaseq-qc
RNA-seq specific quality control including rRNA contamination detection, strandedness verification, gene body coverage, and transcript integrity metrics. Use when validating RNA-seq libraries before differential expression analysis.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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tooluniverse-gwas-finemapping
Identify and prioritize causal variants at GWAS loci using statistical fine-mapping and locus-to-gene predictions. Computes posterior probabilities for causal variants, links variants to genes via L2G predictions, annotates functional consequences, and suggests validation strategies. Use when asked to fine-map GWAS loci, prioritize causal variants, identify credible sets, or link GWAS signals to causal genes.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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tooluniverse-infectious-disease
Rapid pathogen characterization and drug repurposing analysis for infectious disease outbreaks. Identifies pathogen taxonomy, essential proteins, predicts structures, and screens existing drugs via docking. Use when facing novel pathogens, emerging infections, or needing rapid therapeutic options during outbreaks.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-data-visualization-heatmaps-clustering
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-chipseq-differential-binding
Differential binding analysis using DiffBind. Compare ChIP-seq peaks between conditions with statistical rigor. Requires replicate samples. Outputs differentially bound regions with fold changes and p-values. Use when comparing ChIP-seq binding between conditions.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-variant-calling-joint-calling
Joint genotype calling across multiple samples using GATK CombineGVCFs and GenotypeGVCFs. Essential for cohort studies, population genetics, and leveraging VQSR. Use when performing joint genotyping across multiple samples.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009