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Topic: skills

17,247 skills in this topic.

bio-imaging-mass-cytometry-data-preprocessing Load and preprocess imaging mass cytometry (IMC) and MIBI data. Covers MCD/TIFF handling, hot pixel removal, and image normalization. Use when starting IMC analysis from raw MCD files or preparing images for segmentation.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-alignment-indexing
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-flow-cytometry-differential-analysis Differential abundance and state analysis for cytometry data. Compare cell populations between conditions using statistical methods. Use when testing for significant changes in cell frequencies or marker expression between groups.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-genome-engineering-prime-editing-design Design pegRNAs for prime editing using PrimeDesign algorithms. Generate spacer, PBS, and RT template sequences for precise genomic modifications without double-strand breaks. Use when designing prime editing experiments for precise insertions, deletions, or point mutations.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-data-visualization-upset-plots
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-alignment-pairwise Perform pairwise sequence alignment using Biopython Bio.Align.PairwiseAligner. Use when comparing two sequences, finding optimal alignments, scoring similarity, and identifying local or global matches between DNA, RNA, or protein sequences.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-longread-structural-variants Detect structural variants from long-read alignments using Sniffles, cuteSV, and SVIM. Use when detecting deletions, insertions, inversions, translocations, or complex rearrangements from ONT or PacBio data, especially those missed by short-read methods.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-atac-seq-nucleosome-positioning Extract nucleosome positions from ATAC-seq data using NucleoATAC, ATACseqQC, and fragment analysis. Use when analyzing chromatin organization, identifying nucleosome-free regions at promoters, or characterizing nucleosome occupancy patterns from ATAC-seq fragment size distributions.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
adhd-daily-planner Time-blind friendly planning, executive function support, and daily structure for ADHD brains. Specializes in realistic time estimation, dopamine-aware task design, and building systems that actually work for neurodivergent minds.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-hi-c-analysis-hic-visualization Visualize Hi-C contact matrices, TADs, loops, and genomic features using matplotlib, cooltools, and HiCExplorer. Create triangle plots, virtual 4C, and multi-track figures. Use when visualizing contact matrices or genomic features.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-local-blast
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-data-visualization-color-palettes
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-chipseq-super-enhancers Identifies super-enhancers from H3K27ac ChIP-seq data using ROSE and related tools. Use when studying cell identity genes, cancer-associated regulatory elements, or master transcription factor binding regions that cluster into large enhancer domains.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-differential-splicing Detects differential alternative splicing between conditions using rMATS-turbo (BAM-based) or SUPPA2 diffSplice (TPM-based). Reports events with FDR-corrected significance and delta PSI effect sizes. Use when comparing splicing patterns between treatment groups, tissues, or disease states.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-hi-c-analysis-hic-differential Compare Hi-C contact matrices between conditions to identify differential chromatin interactions. Compute log2 fold changes, statistical significance, and visualize differential contact maps. Use when comparing Hi-C contacts between conditions.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-alignment-validation
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-atac-seq-motif-deviation Analyze transcription factor motif accessibility variability using chromVAR. Use when identifying which TF motifs show variable accessibility across samples or conditions in ATAC-seq data.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-clinical-databases-dbsnp-queries Query dbSNP for rsID lookups, variant annotations, and cross-references to other databases. Use when mapping between rsIDs and genomic coordinates or retrieving basic variant information.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-clinical-databases-somatic-signatures Extract and analyze mutational signatures from somatic variants using SigProfiler or MutationalPatterns to characterize mutagenic processes. Use when identifying DNA damage mechanisms or etiology in cancer genomes.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-genome-assembly-assembly-qc
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-expression-matrix-counts-ingest
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-epitranscriptomics-modification-visualization
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
autonomous-oncology-agent
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-basecalling Convert raw Nanopore signal data (FAST5/POD5) to nucleotide sequences using Dorado basecaller. Covers model selection, GPU acceleration, modified base detection, and quality filtering. Use when processing raw Nanopore data before alignment. Guppy is deprecated; use Dorado for all new analyses.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009