Topic: awesome
1,258 skills in this topic.
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parameter-optimization
Explore and optimize simulation parameters via design of experiments (DOE), sensitivity analysis, and optimizer selection. Use for calibration, uncertainty studies, parameter sweeps, LHS sampling, Sobol analysis, surrogate modeling, or Bayesian optimization setup.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-spatial-transcriptomics-spatial-visualization
Visualize spatial transcriptomics data using Squidpy and Scanpy. Create tissue plots with gene expression, clusters, and annotations overlaid on histology images. Use when visualizing spatial expression patterns.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-workflows-smrna-pipeline
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-spatial-transcriptomics-spatial-domains
Identify spatial domains and tissue regions in spatial transcriptomics data using Squidpy and Scanpy. Cluster spots considering both expression and spatial context to define anatomical regions. Use when identifying tissue domains or spatial regions.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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tooluniverse-protein-structure-retrieval
Retrieves protein structure data from RCSB PDB, PDBe, and AlphaFold with protein disambiguation, quality assessment, and comprehensive structural profiles. Creates detailed structure reports with experimental metadata, ligand information, and download links. Use when users need protein structures, 3D models, crystallography data, or mention PDB IDs (4-character codes like 1ABC) or UniProt accessions.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-single-cell-markers-annotation
Find marker genes and annotate cell types in single-cell RNA-seq using Seurat (R) and Scanpy (Python). Use for differential expression between clusters, identifying cluster-specific markers, scoring gene sets, and assigning cell type labels. Use when finding marker genes and annotating clusters.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-atac-seq-differential-accessibility
Find differentially accessible chromatin regions between conditions using DiffBind or DESeq2. Use when comparing chromatin accessibility between treatment groups, cell types, or developmental stages in ATAC-seq experiments.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-single-cell-cell-communication
Infer cell-cell communication networks from scRNA-seq data using CellChat, NicheNet, and LIANA for ligand-receptor interaction analysis. Use when inferring ligand-receptor interactions between cell types.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-rna-quantification-featurecounts-counting
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-small-rna-seq-mirdeep2-analysis
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-small-rna-seq-smrna-preprocessing
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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polars
Fast in-memory DataFrame library for datasets that fit in RAM. Use when pandas is too slow but data still fits in memory. Lazy evaluation, parallel execution, Apache Arrow backend. Best for 1-100GB datasets, ETL pipelines, faster pandas replacement. For larger-than-RAM data use dask or vaex.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-sequence-statistics
Calculate sequence statistics (N50, length distribution, GC content, summary reports) using Biopython. Use when analyzing sequence datasets, generating QC reports, or comparing assemblies.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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structural-variant-calling
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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anndata
This skill should be used when working with annotated data matrices in Python, particularly for single-cell genomics analysis, managing experimental measurements with metadata, or handling large-scale biological datasets. Use when tasks involve AnnData objects, h5ad files, single-cell RNA-seq data, or integration with scanpy/scverse tools.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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pdf-processing
Extract text and tables from PDF files, fill forms, merge documents. Use when working with PDF files or when the user mentions PDFs, forms, or document extraction.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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crisis-response-protocol
Handle mental health crisis situations in AI coaching safely. Use when implementing crisis detection, safety protocols, emergency escalation, or suicide prevention features. Activates for crisis keywords, safety planning, hotline integration, and risk assessment.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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tooluniverse-precision-medicine-stratification
Comprehensive patient stratification for precision medicine by integrating genomic, clinical, and therapeutic data. Given a disease/condition, genomic data (germline variants, somatic mutations, expression), and optional clinical parameters, performs multi-phase analysis across 9 phases covering disease disambiguation, genetic risk assessment, disease-specific molecular stratification, pharmacogenomic profiling, comorbidity/DDI risk, pathway analysis, clinical evidence and guideline mapping, clinical trial matching, and integrated outcome prediction. Generates a quantitative Precision Medicine Risk Score (0-100) with risk tier assignment (Low/Intermediate/High/Very High), treatment algorithm (1st/2nd/3rd line), pharmacogenomic guidance, clinical trial matches, and monitoring plan. Use when clinicians ask about patient risk stratification, treatment selection, prognosis prediction, or personalized therapeutic strategy across cancer, metabolic, cardiovascular, neurological, or rare diseases.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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joint-calling
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-spatial-transcriptomics-spatial-data-io
Load spatial transcriptomics data from Visium, Xenium, MERFISH, Slide-seq, and other platforms using Squidpy and SpatialData. Read Space Ranger outputs, convert formats, and access spatial coordinates. Use when loading Visium, Xenium, MERFISH, or other spatial data.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-rna-quantification-tximport-workflow
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-sequence-properties
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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cryoem-ai-drug-design-agent
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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etetoolkit
Phylogenetic tree toolkit (ETE). Tree manipulation (Newick/NHX), evolutionary event detection, orthology/paralogy, NCBI taxonomy, visualization (PDF/SVG), for phylogenomics.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009