Topic: skills
17,247 skills in this topic.
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bio-epitranscriptomics-merip-preprocessing
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-experimental-design-batch-design
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-clip-seq-clip-preprocessing
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-data-visualization-genome-tracks
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-epidemiological-genomics-variant-surveillance
Assign pathogen lineages and track variants using Nextclade and pangolin for viral surveillance. Monitor variant prevalence and identify emerging variants of concern. Use when classifying viral sequences, tracking lineage dynamics, or monitoring for variants of concern.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-crispr-screens-base-editing-analysis
Analyzes base editing and prime editing outcomes including editing efficiency, bystander edits, and indel frequencies. Use when quantifying CRISPR base editor results, comparing ABE vs CBE efficiency, or assessing prime editing fidelity.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-comparative-genomics-hgt-detection
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-alignment-sorting
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-copy-number-cnv-annotation
Annotate CNVs with genes, pathways, and clinical significance. Use when interpreting CNV calls or identifying affected genes from copy number analysis.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-crispr-screens-batch-correction
Batch effect correction for CRISPR screens. Covers normalization across batches, technical replicate handling, and batch-aware analysis. Use when combining screens from multiple batches or correcting systematic technical variation.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-data-visualization-heatmaps-clustering
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-crispr-screens-hit-calling
Statistical methods for calling hits in CRISPR screens. Covers MAGeCK, BAGEL2, drugZ, and custom approaches for identifying essential and resistance genes. Use when identifying significant genes from screen count data after QC passes.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-alignment-files-bam-statistics
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-entrez-search
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-chipseq-differential-binding
Differential binding analysis using DiffBind. Compare ChIP-seq peaks between conditions with statistical rigor. Requires replicate samples. Outputs differentially bound regions with fold changes and p-values. Use when comparing ChIP-seq binding between conditions.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-clinical-databases-hla-typing
Call HLA alleles from NGS data using OptiType, HLA-HD, or arcasHLA for immunogenomics applications. Use when determining HLA genotype for transplant matching, neoantigen prediction, or pharmacogenomic screening.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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alphafold
Validate protein designs using AlphaFold2 structure prediction. Use this skill when: (1) Validating designed sequences fold correctly, (2) Predicting binder-target complex structures, (3) Calculating confidence metrics (pLDDT, pTM, ipTM), (4) Self-consistency validation of designs, (5) Multi-chain complex prediction with AlphaFold-Multimer.
For faster single-chain prediction, use esm. For QC thresholds, use protein-qc.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-consensus-sequences
Generate consensus FASTA sequences by applying VCF variants to a reference using bcftools consensus. Use when creating sample-specific reference sequences or reconstructing haplotypes.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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adaptyv
Cloud laboratory platform for automated protein testing and validation. Use when designing proteins and needing experimental validation including binding assays, expression testing, thermostability measurements, enzyme activity assays, or protein sequence optimization. Also use for submitting experiments via API, tracking experiment status, downloading results, optimizing protein sequences for better expression using computational tools (NetSolP, SoluProt, SolubleMPNN, ESM), or managing protein design workflows with wet-lab validation.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-epidemiological-genomics-amr-surveillance
Detect and track antimicrobial resistance genes using AMRFinderPlus and ResFinder with epidemiological context. Monitor resistance trends and identify emerging resistance patterns. Use when screening genomes for AMR genes or tracking resistance in surveillance programs.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-data-visualization-ggplot2-fundamentals
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-causal-genomics-colocalization-analysis
Test whether two traits share a causal variant at a genomic locus using Bayesian colocalization with coloc. Computes posterior probabilities for shared vs distinct causal variants between GWAS and eQTL signals. Use when determining if a GWAS signal and an eQTL share the same causal variant.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-codon-usage
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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agentd-drug-discovery
FreedomIntelligence/OpenClaw-Medical-Skills 2,009