Topic: awesome
1,258 skills in this topic.
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bio-workflows-somatic-variant-pipeline
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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tooluniverse-immunotherapy-response-prediction
Predict patient response to immune checkpoint inhibitors (ICIs) using multi-biomarker integration. Given a cancer type, somatic mutations, and optional biomarkers (TMB, PD-L1, MSI status), performs systematic analysis across 11 phases covering TMB classification, neoantigen burden estimation, MSI/MMR assessment, PD-L1 evaluation, immune microenvironment profiling, mutation-based resistance/sensitivity prediction, clinical evidence retrieval, and multi-biomarker score integration. Generates a quantitative ICI Response Score (0-100), response likelihood tier, specific ICI drug recommendations with evidence, resistance risk factors, and a monitoring plan. Use when oncologists ask about immunotherapy eligibility, checkpoint inhibitor selection, or biomarker-guided ICI treatment decisions.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-workflow-management-wdl-workflows
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-pathway-reactome
Reactome pathway enrichment using ReactomePA package. Use when analyzing gene lists against Reactome's curated peer-reviewed pathway database. Performs over-representation analysis and GSEA with visualization and pathway hierarchy exploration.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-basecalling
Convert raw Nanopore signal data (FAST5/POD5) to nucleotide sequences using Dorado basecaller. Covers model selection, GPU acceleration, modified base detection, and quality filtering. Use when processing raw Nanopore data before alignment. Guppy is deprecated; use Dorado for all new analyses.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-metabolomics-xcms-preprocessing
XCMS3 workflow for LC-MS/MS metabolomics preprocessing. Covers peak detection, retention time alignment, correspondence (grouping), and gap filling. Use when processing raw LC-MS data into a feature table for untargeted metabolomics.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-clinical-databases-somatic-signatures
Extract and analyze mutational signatures from somatic variants using SigProfiler or MutationalPatterns to characterize mutagenic processes. Use when identifying DNA damage mechanisms or etiology in cancer genomes.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-small-rna-seq-target-prediction
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-pathway-go-enrichment
Gene Ontology over-representation analysis using clusterProfiler enrichGO. Use when identifying biological functions enriched in a gene list from differential expression or other analyses. Supports all three ontologies (BP, MF, CC), multiple ID types, and customizable statistical thresholds.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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wellally-tech
Integrate digital health data sources (Apple Health, Fitbit, Oura Ring) and connect to WellAlly.tech knowledge base. Import external health device data, standardize to local format, and recommend relevant WellAlly.tech knowledge base articles based on health data. Support generic CSV/JSON import, provide intelligent article recommendations, and help users better manage personal health data.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-imaging-mass-cytometry-data-preprocessing
Load and preprocess imaging mass cytometry (IMC) and MIBI data. Covers MCD/TIFF handling, hot pixel removal, and image normalization. Use when starting IMC analysis from raw MCD files or preparing images for segmentation.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-machine-learning-prediction-explanation
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-multi-omics-data-harmonization
Preprocessing and harmonization of multi-omics data before integration. Covers normalization, batch correction, feature alignment, and missing value handling across data types. Use when preparing multi-omics datasets for integration analysis.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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tooluniverse-clinical-trial-matching
AI-driven patient-to-trial matching for precision medicine and oncology. Given a patient profile (disease, molecular alterations, stage, prior treatments), discovers and ranks clinical trials from ClinicalTrials.gov using multi-dimensional matching across molecular eligibility, clinical criteria, drug-biomarker alignment, evidence strength, and geographic feasibility. Produces a quantitative Trial Match Score (0-100) per trial with tiered recommendations and a comprehensive markdown report. Use when oncologists, molecular tumor boards, or patients ask about clinical trial options for specific cancer types, biomarker profiles, or post-progression scenarios.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-metabolomics-statistical-analysis
Statistical analysis for metabolomics data. Covers univariate testing, multivariate methods (PCA, PLS-DA), and biomarker discovery. Use when identifying differentially abundant metabolites or building classification models.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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autonomous-oncology-agent
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-microbiome-amplicon-processing
Amplicon sequence variant (ASV) inference from 16S rRNA or ITS amplicon sequencing using DADA2. Covers quality filtering, error learning, denoising, and chimera removal. Use when processing demultiplexed amplicon FASTQ files to generate an ASV table for downstream analysis.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-microbiome-functional-prediction
Predict metagenome functional content from 16S rRNA marker gene data using PICRUSt2. Infer KEGG, MetaCyc, and EC abundances from ASV tables. Use when functional profiling is needed from 16S data without shotgun metagenomics sequencing.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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wearable-analysis-agent
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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gwas-database
Query NHGRI-EBI GWAS Catalog for SNP-trait associations. Search variants by rs ID, disease/trait, gene, retrieve p-values and summary statistics, for genetic epidemiology and polygenic risk scores.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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molecular-dynamics
Run and analyze molecular dynamics simulations with OpenMM and MDAnalysis. Set up protein/small molecule systems, define force fields, run energy minimization and production MD, analyze trajectories (RMSD, RMSF, contact maps, free energy surfaces). For structural biology, drug binding, and biophysics.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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kragen-knowledge-graph
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-primer-design-primer-validation
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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prs-net-deep-learning-agent
FreedomIntelligence/OpenClaw-Medical-Skills 2,009