Topic: claude-code
35,830 skills in this topic.
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bio-clip-seq-clip-preprocessing
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-chipseq-motif-analysis
De novo motif discovery and known motif enrichment analysis using HOMER and MEME-ChIP. Identify transcription factor binding motifs in ChIP-seq, ATAC-seq, or other genomic peak data. Use when finding enriched DNA motifs in peak sequences.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-crispr-screens-hit-calling
Statistical methods for calling hits in CRISPR screens. Covers MAGeCK, BAGEL2, drugZ, and custom approaches for identifying essential and resistance genes. Use when identifying significant genes from screen count data after QC passes.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-long-read-sequencing-clair3-variants
Deep learning-based variant calling from long reads using Clair3 for SNPs and small indels. Use when calling germline variants from ONT or PacBio alignments, particularly when high accuracy is needed for clinical or research applications.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-data-visualization-ggplot2-fundamentals
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-immunoinformatics-tcr-epitope-binding
Predict TCR-epitope specificity using ERGO-II and deep learning models for T-cell receptor antigen recognition. Match TCRs to their cognate epitopes or predict TCR targets. Use when analyzing TCR repertoire specificity or identifying antigen-reactive T-cells.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-chipseq-differential-binding
Differential binding analysis using DiffBind. Compare ChIP-seq peaks between conditions with statistical rigor. Requires replicate samples. Outputs differentially bound regions with fold changes and p-values. Use when comparing ChIP-seq binding between conditions.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-epitranscriptomics-merip-preprocessing
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-geo-data
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-entrez-search
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-epidemiological-genomics-amr-surveillance
Detect and track antimicrobial resistance genes using AMRFinderPlus and ResFinder with epidemiological context. Monitor resistance trends and identify emerging resistance patterns. Use when screening genomes for AMR genes or tracking resistance in surveillance programs.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-atac-seq-atac-qc
Quality control metrics for ATAC-seq data including fragment size distribution, TSS enrichment, FRiP, and library complexity. Use when assessing ATAC-seq library quality before or after peak calling to identify problematic samples.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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adaptyv
Cloud laboratory platform for automated protein testing and validation. Use when designing proteins and needing experimental validation including binding assays, expression testing, thermostability measurements, enzyme activity assays, or protein sequence optimization. Also use for submitting experiments via API, tracking experiment status, downloading results, optimizing protein sequences for better expression using computational tools (NetSolP, SoluProt, SolubleMPNN, ESM), or managing protein design workflows with wet-lab validation.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-crispr-screens-batch-correction
Batch effect correction for CRISPR screens. Covers normalization across batches, technical replicate handling, and batch-aware analysis. Use when combining screens from multiple batches or correcting systematic technical variation.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-immunoinformatics-neoantigen-prediction
Identify tumor neoantigens from somatic mutations using pVACtools for personalized cancer immunotherapy. Predict mutant peptides that bind patient HLA and may elicit T-cell responses. Use when identifying vaccine targets or checkpoint inhibitor response biomarkers from tumor sequencing data.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-causal-genomics-colocalization-analysis
Test whether two traits share a causal variant at a genomic locus using Bayesian colocalization with coloc. Computes posterior probabilities for shared vs distinct causal variants between GWAS and eQTL signals. Use when determining if a GWAS signal and an eQTL share the same causal variant.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-longitudinal-monitoring
Tracks ctDNA dynamics over time for treatment response monitoring using serial liquid biopsy samples. Analyzes tumor fraction trends, mutation clearance kinetics, and defines molecular response criteria. Use when monitoring patients during therapy or detecting molecular relapse before clinical progression.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-data-visualization-heatmaps-clustering
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-codon-usage
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-genome-assembly-assembly-polishing
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-clinical-databases-polygenic-risk
Calculate polygenic risk scores using PRSice-2, LDpred2, or PRS-CS from GWAS summary statistics. Use when predicting disease risk from genome-wide genetic variants.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-alignment-sorting
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-experimental-design-batch-design
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
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bio-consensus-sequences
Generate consensus FASTA sequences by applying VCF variants to a reference using bcftools consensus. Use when creating sample-specific reference sequences or reconstructing haplotypes.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009